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Be an valuable anticancer strategy, for certain tumor forms. In this
Be an useful anticancer tactic, for certain tumor sorts. Within this context, additional research is going to be required to greater define the nuclear effects of GRK5 and thepossibility to regulate its subcellular localization in order to regulate its functions within the tumor cell as required.
Send Orders for Reprints to reprints@benthamscience.ae420 The Open Dentistry Journal, 2016, ten, 420-The Open Dentistry JournalContent list readily available at: DOI: ten.2174/RESEARCH ARTICLEAre Pediatric Antibiotic Formulations Potentials Danger fnins.2015.00094 Factors for Dental Caries and Dental Erosion?Ana Carolina Valinoti1, Luiz Carlos da Costa Jr.2, Adriana Farah3, Val ia Pereira de Sousa4, Andr Fonseca-Gon lves1 and Lucianne Cople Maia*,Department of Pediatric Dentistry and Orthodontics, College of Dentistry, Universidade CBR-5884 site Federal do Rio de Janeiro, RJ, Brazil two Systems and Computing Engineering, COPPE/ Universidade Federal do Rio de Janeiro, RJ, Brazil three Institute of Nutrition, Universidade Federal do Rio de Janeiro, RJ, Brazil 4 Good quality Handle of Drugs and Medicines Laboratory, Division of Medicines, Universidade Federal do Rio de Janeiro, RJ, BrazilReceived: February 16, 2015 Revised: June 20, 2016 Accepted: July 15,Abstract: Introduction: One of essentially the most frequent parents' issues is the fact that oral antibiotic formulations induce dental damage in their children's. This study aimed to assess the cariogenic and erosive potentials of 29 pediatric antibiotics. Components and Techniques: Replicates of each antibiotic have been analyzed for the concentration of sugars (sucrose, glucose and fructose) and sorbitol by high fpsyg.2015.00360 efficiency liquid chromatography (HPLC). The pH was determined by digital pHmeter. Titratable acidity was determined in triplicate making use of the identical pHmeter by gradual addition of 0.1N sodium hydroxide (NaOH) until pH 7.0. Viscosity measurements had been carried out working with a viscosimeter. In an effort to rank the relative performance of every single medicine, the DEA (Data Envelopment Evaluation) methodology was utilized. Results: Sucrose was present in most samples (n=24) with concentrations ranging from 26 to 100g (w/w). Only one antibiotic contained sorbitol (66.9g ). Twenty seven antibiotics presented pH values ranging from 4.1 to six.9 and the majority of them (n=15) showed the pH below the critical value for dissolution of hydroxyapatite. The values of titratable acidity and viscosity ranged from 0.26 to 40.48 ml and from 20 to 1780cP, respectively. DEA methodology showed that two medicines have been distant in the performance frontier (Klaricid?50mg and Zinnat?250mg), which indicates that these medicines showed the worst functionality and, consequently, greater possible for dissolution of dental enamel. Conclusion: Numerous antibiotics presented higher concentration of sugars, high titratable acidity, pH below the critical value and higher viscosity which is often thought of danger components for dental caries and erosion, when consumed regularly. Keyword phrases: Antibiotics, Dental caries, Pharmaceutical preparations, Sweetening agents, Tooth erosion, Viscosity.* Address correspondence to this author at the Cidade Universitaria-CCS, Caixa, 68066, CEP: 21941-971, Rio de Janeiro, Brazil; Tel/Fax: 00 55 21 2562.2098; Email: Bentham OpenCariogenic and Erosive Potentials of AntibioticsThe Open Dentistry Journal, 2016, Volume 10INTRODUCTION Liquid oral medicines include in their formulation agents to improve their look, bioavailability, stability, and palatability [1].

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